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If you’re experiencing severe abdominal pain, fever, or heavy bleeding, call 911.

Pancreatic Cancer

Pancreatic Cancer Explained

Pancreatic cancer often develops silently and may not cause specific symptoms until it is advanced. When symptoms appear, they may include abdominal or back pain, weight loss, jaundice, and new-onset diabetes. Treatment depends on the stage and may involve surgery, chemotherapy, radiation, or combinations of these therapies.

Symptoms

Symptoms are often vague, which can delay diagnosis. Persistent, unexplained symptoms—especially in people at higher risk—deserve prompt evaluation.

Symptoms include:
Upper abdominal or back pain
Unexplained weight loss or loss of appetite
Jaundice (yellow skin/eyes), dark urine, or pale stools
Nausea, bloating, or indigestion
New-onset diabetes or a sudden change in existing diabetes control

When to call

Call the office if you have unexplained weight loss, persistent abdominal or back pain, jaundice, or new-onset diabetes, especially if you have known risk factors for pancreatic cancer.

Seek emergency care for severe abdominal pain, uncontrolled vomiting, high fever, sudden jaundice with severe itching, or signs of blood clots (arm or leg swelling and pain, shortness of breath).

Evaluation & Tests
Management & Treatment

Evaluation involves imaging (CT, MRI, or endoscopic ultrasound), blood tests, and biopsy to confirm the diagnosis and determine stage. High-risk patients may be considered for specialized screening programs.

Full history and exam, including risk factors (family history, genetic syndromes, chronic pancreatitis, smoking)
Cross-sectional imaging (contrast CT or MRI) of the pancreas
Endoscopic ultrasound with fine-needle biopsy to confirm the diagnosis when needed
Blood tests including liver function and sometimes tumor markers
Multidisciplinary review to determine stage and treatment plan

Treatment options depend on whether the cancer can be surgically removed. Early-stage disease may be treated with surgery plus chemotherapy. More advanced disease typically relies on chemotherapy, radiation, and supportive care to control symptoms and improve quality of life.

Surgical resection (when possible) offers the best chance for long-term survival
Chemotherapy and sometimes radiation before or after surgery, or as primary treatment
Management of symptoms such as pain, weight loss, and jaundice
Genetic counseling/testing in selected patients
Palliative and supportive care at all stages to maintain comfort and quality of life
This information is for general educational purposes only and is not a diagnosis or personalized medical advice. It does not replace a visit with your own healthcare provider. Always follow the specific recommendations given by your medical team. If you have urgent or worsening symptoms, contact your provider or seek emergency care right away.

At-a-glance

Abdominal painWeight loss / anemia

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Information on this website is for education only and not a substitute for medical advice.

If you’re experiencing an emergency, call 911.
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