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Peptic Ulcer Disease

Peptic Ulcer Disease Explained

Peptic ulcer disease refers to ulcers in the stomach (gastric ulcers) or duodenum (the first part of the small intestine). These sores develop when the protective lining is weakened and acid damages the underlying tissue. The most common causes are infection with Helicobacter pylori bacteria and frequent use of nonsteroidal anti-inflammatory drugs (NSAIDs), though other factors can contribute.

Ulcers can cause burning or gnawing upper abdominal pain, sometimes with nausea, bloating, or early fullness. If severe, they can bleed or perforate, which are medical emergencies. Effective treatments are available to eradicate H. pylori, reduce acid, and help the lining heal.

Síntomas

Symptoms vary from mild discomfort to severe pain or bleeding. Many people notice a dull or burning pain in the upper abdomen, often related to meals, but some ulcers cause few or no symptoms until a complication occurs.

Los síntomas incluyen:
Burning or gnawing pain in the upper abdomen, sometimes improving or worsening with food
Nausea or queasiness
Bloating, belching, or early fullness
Loss of appetite or unintentional weight loss
Dark, tarry stools or vomiting blood (signs of bleeding)

Cuándo llamar

Call the office if you have persistent upper abdominal pain, nausea, early fullness, or unexplained weight loss, especially if you use NSAIDs regularly or have a history of ulcers. Also call if pain or heartburn do not improve on medication.

Seek emergency care immediately for vomiting blood, coffee-ground material, or black/tarry stools; sudden, severe abdominal pain; feeling faint or passing out; or signs of shock (confusion, rapid heartbeat, cold/clammy skin). These may indicate bleeding or perforation and require urgent treatment.

Evaluación y pruebas
Manejo y tratamiento

Evaluation typically includes a careful history, tests for H. pylori, and often upper endoscopy to directly visualize the stomach and duodenum, especially when there are alarm symptoms or risk factors.

Review of pain pattern, medication use (particularly NSAIDs, aspirin, blood thinners), alcohol and tobacco use
Testing for H. pylori (breath test, stool test, or biopsy at endoscopy)
Upper endoscopy to confirm an ulcer, rule out cancer (particularly in gastric ulcers), and evaluate for bleeding
Laboratory tests such as blood counts if bleeding or anemia is suspected
Follow-up endoscopy in selected cases to confirm healing (especially gastric ulcers or high-risk lesions)

Treatment focuses on removing the cause, healing the ulcer, and preventing recurrence or complications. This usually involves eradicating H. pylori when present, reducing or stopping NSAIDs when possible, and taking acid-suppressing medicine for a prescribed course.

Antibiotic-based regimens plus a PPI to eradicate H. pylori when infection is detected
Stopping or minimizing NSAIDs and other offending drugs when medically safe
Proton pump inhibitors or other acid-suppressing medicines to promote healing
Avoidance of tobacco and moderation of alcohol use
Regular follow-up to ensure symptoms resolve and to reassess if pain, anemia, or bleeding recur
Esta información tiene únicamente fines educativos generales y no constituye un diagnóstico ni un consejo médico personalizado. No sustituye la consulta con su propio profesional sanitario. Siga siempre las recomendaciones específicas que le haya dado su equipo médico. Si presenta síntomas urgentes o que empeoran, póngase en contacto con su profesional sanitario o acuda inmediatamente a urgencias.

De un vistazo

Abdominal painNausea / vomitingWeight loss / anemia

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